Determinants of Household Solid Waste Generation and Composition in Homs City, Syria.

The absence of accurate information on the state of waste is a challenge to the solid waste management system in Syria. The local authorities commonly estimate the quantity of waste produced and its characterisation, which is the starting point for solid waste management planning. So, this paper aims to evaluate the generation and composition of household solid waste in Homs city, Syria. Also, the study presents factors influencing the waste generation rate and the waste composition. The study was carried out in 300 families from four zones in Homs city, and three sampling stages were conducted during the study duration, which started in July 2017 and ended in February 2019. The outcomes show that an average of 0.68 kg/per/day solid waste generated was calculated for the entire study area in Homs city. Also, the data analysis presents that organic waste constitutes the largest component in the waste mixture (69.1%) followed by plastic (10.6%), inert materials (8.7%), paper (4.6%), textile (2.5%), metal (1.2%), glass (1.1%), wood (0.6%), and hazardous materials (1.6%). The multiple linear regression results showed that the adjusted R 2 value was found to be 0.557, 0.839, and 0.709 for the waste generation per capita, the daily household organic waste generation, and the daily household packaging waste generation, respectively. Also, according to Pearson's coefficient values, a positive correlation was found between household waste generation and monthly income (r = 0.626), household size (r = 0.37), and age of the household head (r = 0.517), whereas a negative correlation was found between household waste generation and the education level of the household head (r = -0.649).

Root extract of Prunella vulgaris inhibits in vitro and in vivo carcinogenesis in MCF-5 human breast carcinoma via suppression of angiogenesis, induction of apoptosis, cell cycle arrest and modulation of PI3K/AKT signalling pathway.

PURPOSE: In this study we examined the anticancer effects of methanolic root extract of Prunella Vulgaris (PVE) against the MCF-5 breast cancer (BC) cell line along with its mode of action. METHODS: The proliferation rate of the MCF-5 cells was assessed by MTT assay. Apoptosis was confirmed by acridine orange (AO)/ethidium bromide (EB) and annexin V/propidium iodide (PI) staining. DNA damage was checked by comet assay. Cell cycle analysis was performed by flow cytometry. Protein expression was determined by western blotting. In vivo evaluation of the extract was carried out in xenografted tumor mice models. RESULTS: PVE inhibited the growth of the MCF-5 cells and exhibited an IC50 value of 25 µg/ml. The investigation of underlying mechanism revealed that PVE triggered apoptotic cell death of the MCF-5 cells which was also associated with enhancement of the expression of Bax and decrease in the expression of Bcl-2. PVE also caused arrest of the cells in the G2/M phase of the cell cycle and also exerted the anti-angiogenic effects. In vivo evaluation of PVE showed that it could inhibit the tumor weight and volume, suggestive of the anticancer potential of PVE. CONCLUSION: The root extract of Prunella vulgaris in this study was shown to exert potent anticancer effects in MCF-7 human BC cells both in vitro and in vivo, accompanied with apoptosis induction, inhibition of angiogenesis, cell cycle arrest, and modulation of PI3K/AKT signaling pathway.

[Role of adenosine triphosphate-sensitive potassium channel in hydrogen sulfide-induced inhibition of high glucoseinduced osteoblast damage].

OBJECTIVE: The aim of this study is to identify the role of adenosine triphosphate-sensitive potassium channel (KATP) in hydrogen sulfide (H2S)-induced inhibition of high glucose (HG)-induced osteoblast damage. METHODS: Osteoblasts from rat mandible were cultured and identified. The osteoblasts were then treated with HG, H2S, KATP channel opener pinacidil (Pia), and KATP channel blocker glibenclamide (Gli). Western blot method was performed to detect the expression of KATP channel protein. CCK8, reverse transcriptase polymerase chain reaction (RT-PCR) , and image analysis were used to determine the effects of H2S-KATP on the proliferation, differentiation, and mineralization of osteoblasts. RESULTS: The expression of KATP channel protein in osteoblasts was significantly decreased under the influence of HG. H2S pretreatment significantly inhibited HG on KATP channel protein down-regulation. Moreover, H2S pretreatment significantly inhibited the effect of HG on the proliferation of osteoblasts, thereby preventing HG-induced inhibition of osteoblasts differentiation and mineralization. Meanwhile, the KATP channel blocker effectively blocked the H2S on osteoblasts and had a protective effect. CONCLUSIONS: Through the KATP channel, H2S inhibited osteoblasts damage induced by HG.

[Cone beam computed tomography evaluation of bifid mandibular canals in the adult population in Sichuan Province].

OBJECTIVE: To investigate the incidence of bifid mandibular canals (BMC), and analyze the types, courses, and anatomic features of the variant canals in the adult population in Sichuan Province. METHODS: Five hundred patients (1 000 hemimandibles) underwent cone beam computed tomography (CBCT) were included in this study. The incidence, bifurcate types and courses of the BMC were evaluated. RESULTS: The incidence of BMC was 13.8% (69/500) in the study, 9.2% in terms of total hemimandibles. The most frequently type was retromolar canals, followed by the dental and buccolingual type, meanwhile the lowest was the forward type. The mean diameter of the accessory canals was 0.90 mm and the mean length was 9.39 mm. CONCLUSIONS: CBCT used in this study has shown that the incidence of BMC assessed by CBCT was significantly higher than panoramic radiography. Furthermore, CBCT can depict the position, course, size and the branches of the mandibular canals.
.

Developing a one-channel BCI system using a dry claw-like electrode.

An eight-class SSVEP-based BCI system was designed and demonstrated in this study. To minimize the complexity of the traditional equipment and operation, only one work electrode was used. The work electrode was fabricated in our laboratory and designed as a claw-like structure with a diameter of 15 mm, featuring 8 small fingers of 4mm length and 2 mm diameter, and the weight was only 0.1g. The structure and elasticity can help the fingers pass through the hair and contact the scalp when placed on head. The electrode was capable to collect evoked brain activities such as steady-state visual evoked potentials (SSVEPs). This study showed that although the amplitude and SNR of SSVEPs obtained from a dry claw electrode was relatively lower than that from a wet electrode, the difference was not significant. This study further implemented an eight-class SSVEP-based BCI system using a dry claw-like electrode. Three subjects participated in the experiment. Using infinite impulse response (IIR) filtering and a simplified threshold method based on fast Fourier transform (FFT), the average accuracy of the three participants was 89.3% using 4 sec-long SSVEPs, leading to an average information transfer rate (ITR) of 26.5 bits/min. The results suggested the ability of using a dry claw-like electrode to perform practical BCI applications.

A sapphire based monolithic integrated optrode.

A novel kind of optrode fabricated on a sapphire substrate is proposed for optogenetic applications in neuroscience. Eight thin-film neural electrodes and a GaN-LED are monolithically integrated on the surface of a sapphire shank. The LED is used for optogenetic stimulation and the multiple electrodes are used for simultaneous recording of neural activities. The output power density of the LED is 1-19 mW/mm2 at 468 nm, driving with a current from 0.7-10 mA. The mean electrochemical impedance of the eight recoding sites on the optrode at 1 kHz is 385 kΩ. The highest temperature-raise at tissue around the LED is almost 1 °C when the output power density is 3 mw/mm2. The monolithic integrated structure will make it a powerful tool for optogenetics.

Application and Analysis of Biological Electrospray in Tissue Engineering.

Nan-fiber scaffolds are suitable tools for tissue engineering. Electro spinning materials together with cells presents not adequate to obtain a high cellular zing tissue constructs as the shear force, tensile force, and other physical effects excited in the electro spinning process, which are harmful to cellular differentiation, development and function. However, this limitation has been overcome by a micro integration system of simultaneously bio-electro spraying human adipose stem cells (ASCs) and electro spinning Polyvinyl alcohol (PVA). Then it was compared to the single electro spinning nan-fiber scaffolds in relation to cell viability, which showed that the scaffolds by micro integration approach has a larger number of surviving cells and more suitable for cell growth and proliferation. In addition, the relationship between different parameters of biological electrospray (voltage, flow rate and distance of the needle from the collecting board) and droplet size of cell suspension was elucidated and the droplets with a near-mono distribution (<50um) could be generated to deposit a single living cell within a droplet. The association of bio-electro spraying with electro spinning (a scaffold preparation technique) has been demonstrated to be a promising and suitable tissue engineering approach in producing nan-fiber based three-dimensional (3-D) cell seeded scaffolds.

[Application of double pedicle sliding skin flap in cryptotia correction].

OBJECTIVE: To explor the curative effect of double pedicle sliding skin flap for correction of cryptotia. METHODS: From January 2011 to October 2014, 7 cases with cryptotia (12 ears) were treated. We designed a double pedicle sliding skin flap above the helix. The flap was slided downward to form a new auriculocephalic sulcus. The other wound was covered by skin graft. RESULTS: All wounds healed very well with no complication. The follow-up period ranged from 3 months to 1 year, with an average of (5.67 ± 3.38) months. The ear had stable appearance with no recurrence. The result was satisfactory. CONCLUSIONS: The method is simple with reliable flap survival rates. The new auriculocephalic sulcus is stable and resistant. It's a good choice for correction of cryptotia.

[Keratocystic odontogenic tumor with malignant transformation: a case report].

The keratocystic odontogenic tumor (KCOT) is a common cystic lesions of jaw, which has a high recurrence rate but rarely undergo malignant transformation. This study reported a patient with primary intraosseous squamous cell carcinoma developed from KCOT.

[Reconstruction of facial soft tissue defects with pedicled expanded flaps].

OBJECTIVE: To investigate the application of pedicled expanded flaps for the reconstruction of facial soft tissue defects. METHODS: The expanded skin flaps, pedicled with orbicularis oculi muscle, submental artery, the branch of facial artery, superficial temporal artery, interior upper arm artery, had similar texture and color as facial soft tissue. The pedicled expanded flaps have repaired the facial soft tissue defects. RESULTS: Between Jan. 2003 to Dec. 2013, 157 cases with facial soft tissue defects were reconstructed by pedicled expanded flaps. Epidermal necrosis happened at the distal end of 8 expanded flaps, pedicled with interior upper arm artery(4 cases), orbicularis oculi muscle(3 cases) and submental artery(1 case), which healed spontaneously after dressing. All the other flaps survived completely with similar color and inconspicuous scar. 112 cases were followed up for 8 months to 8 years. Satisfactory results were achieved in 75 cases. 37 cases with hypertrophic scar at incisions need secondary operation. CONCLUSIONS: Island pedicled expanded flap with similar texture and color as facial soft tissue is suitable for facial soft tissue defects. The facial extra-incision and large dog-ear deformity could be avoided.

[Cone beam CT radiographic diagnosis of submandibular radiopaque sialolithiasis].

OBJECTIVE: To investigate the radiographic features of submandibular sialiths in cone beam CT (CBCT) images. METHODS: Eighty-four patients with submandibular radiopaque sialiths were included in this study. The clinical features of gender and age and the radiographic features on CBCT, including the number, morphology, size, and location, were recorded for further statistical analysis. RESULTS: A total of 128 sialiths were detected from the 84 subjects; 22 subjects (26.19%) had multiple sialiths. The morphology of the sialiths was classified into five types: spot, round, spheroid, elongated, and irregular shapes. Among these types, the spheroid shape was the most frequently detected. A correlation was observed between the size of the sialiths and their location, with the large sialith located at the posterior portion of the duct. About 39.06% (50/128) of sialiths was located at the anterior portion of the duct, and 60.94% (78/128) was located at the posterior portion. The horizon- tal position of the sialith was significantly correlated with its vertical position (P < 0.0001). CONCLUSION: The CBCT images showed important data for the evaluation, diagnosis, and treatment plan of the submandibular sialolithiasis.